Endocrine Abstracts

Background: The relationship between energy balance and reproduction is U-shaped, meaning that both a negative and a positive energy balance have a detrimental effect on reproductive function. In a world increasingly burdened by the growing prevalence of obesity, we turned our attention to the negative extremity of weight, by exploring anorexia nervosa (AN) and constitutional thinness (CT) metabolic and reproductive features. Kisspeptin (kiss-1) is a relatively recently discov...

Background: Iatrogeny is the most common cause of Cushing syndrome (CS), with most reported cases due to prolonged use of oral, parenteral or, rarely, topical corticosteroid preparations. Few cases of CS (and consecutive adrenal insufficiency (AI)) due to intranasal corticoids have been reported and the vast majority were documented in pediatric patients.Case reports: We present two cases of iatrogenic CS due to chronic intranasal administration of over-...